Spigelia aceifolia- Spigelia alabamensis
- Spigelia amazonica
- Spigelia amplexicaulis
- Spigelia andersonii
- Spigelia anthelmia
- Spigelia asperifolia
- Spigelia beyrichiana
- Spigelia blanchetiana
- Spigelia brachystachya
- Spigelia breviflora
- Spigelia caaguazuensis
- Spigelia carnosa
- Spigelia cascatensis
- Spigelia chiapensis
- Spigelia coelestyloides
- Spigelia cremnophila
- Spigelia dusenii
- Spigelia elongata
- Spigelia flava
- Spigelia flemingiana
- Spigelia gentianoides
- Spigelia genuflexa
- Spigelia gracilis
- Spigelia granitica
- Spigelia guaranitica
- Spigelia guianensis
- Spigelia hamelioides
- Spigelia hassleriana
- Spigelia hedyotidea
- Spigelia heliotropoides
- Spigelia herzogiana
- Spigelia hurleyi
- Spigelia incana
- Spigelia kleinii
- Spigelia kuhlmannii
- Spigelia laevigata
- Spigelia laurina
- Spigelia leiocarpa
- Spigelia linarioides
- Spigelia loganioides
- Spigelia longiflora
- Spigelia lundheimeri
- Spigelia lundiana
- Spigelia macrophylla
- Spigelia marilandica
- Spigelia martiana
- Spigelia megapotamica
- Spigelia mexicana
- Spigelia meziana
- Spigelia monantha
- Spigelia nicotianaeflora
- Spigelia nicotianiflora
- Spigelia novogranatensis
- Spigelia olfersiana
- Spigelia paraguarensis
- Spigelia paraguariensis
- Spigelia pauciflora
- Spigelia pedunculata
- Spigelia persicarioides
- Spigelia petiolata
- Spigelia polystachya
- Spigelia pubescens
- Spigelia pulchella
- Spigelia pusilla
- Spigelia pygmaea
- Spigelia quaternata
- Spigelia ramosa
- Spigelia riedeliana
- Spigelia riparia
- Spigelia rojasiana
- Spigelia scabra
- Spigelia scabrella
- Spigelia schlechtendaliana
- Spigelia sellowiana
- Spigelia spartioides
- Spigelia speciosa
- Spigelia sphagnicola
- Spigelia splendens
- Spigelia spruceana
- Spigelia stenocardia
- Spigelia stenophylla
- Spigelia tetraptera
- Spigelia texana
- Spigelia trispicata
- Spigelia uleana
- Spigelia valenzuelae
- Spigelia vestita